Fig. 4

Quantitation of PDI in streptavidin precipitates from PBMC extracts prepared from ALS patients (ALS) or healthy individuals (H), under native vs denatured conditions after photocrosslinking with PAV-073 analog (THIQ) or control crosslinker lacking the drug ligand. Both control and THIQ crosslinkers contain biotin and diazirine as described in methods and previously [14]