Fig. 1

A Silver stain of starting PBMC extract 10kxg/10 min supernatant from a representative healthy individual (#52) and an ALS patient (#78-2). B Silver stain of free drug eluate from ALS-active assembly modulator drug resin (column 455 THIQ) or control resin (column 134 lacking the drug ligand). Black arrows indicate positions at which healthy vs ALS patient samples show a suggestive difference in the free drug eluate protein pattern