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Table 2 Proteins differentially expressed between cutaneous leishmaniasis lesions and normal skin

From: Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka

No

Gene name

Protein name

UniProt entry no

Expression change

Differential count

p value

1

OGN

Osteoglycin

P20774

Down-regulated

− 5.40804

0.00004

2

PSME1

Proteosome activator subunit 1

Q06323

Up-regulated

3.694107

0.00006

3

MYH9

Myosin heavy chain 9

P35579

Up-regulated

3.446596

0.00016

4

TMPO

Thymopoietin

P42167

Up-regulated

3.684351

0.00017

5

WARS

Tryptophanyl-tRNA synthetase

P23381

Up-regulated

4.278906

0.00018

6

HMGB2

High mobility group protein B2

P26583

Up-regulated

4.404784

0.00026

7

PDIA3

Protein disulfide isomerase family A, member 3

P30101

Up-regulated

2.543599

0.00026

8

PRKCSH

Glucosidase II subunit beta

P14314

Up-regulated

2.828193

0.00026

9

HSPE1

Heat shock 10 kDa protein 1

P61604

Up-regulated

2.54253

0.00032

10

COTL1

Coactosin-like protein1

Q14019

Up-regulated

5.028113

0.00034

11

LAP3

Leucine aminopeptidase 3

P28838

Up-regulated

3.705696

0.00034

12

RPL6

Ribosomal protein L6

Q02878

Up-regulated

2.863634

0.00034

13

MSN

Moesin

P26038

Up-regulated

3.597755

0.00034

14

IVL

Involucrin

P07476

Up regulated

3.36279

0.00053

15

TYMP

Thymidine phosphorylase

P19971

Up-regulated

4.070576

0.00053

16

CALM1

Calmodulin1

P0DP23

Up-regulated

3.270649

0.00068

17

HMGB1

High mobility group protein B1

P09429

Up-regulated

3.500734

0.00068

18

S100A9

S100 calcium-binding protein A9

P06702

Up-regulated

2.918428

0.00078

19

MZB1

Marginal zone B and B1 cell-specific protein

Q8WU39

Up-regulated

3.95914

0.00087

20

CORO1A

Coronin, actin-binding protein, 1A

P31146

Up-regulated

2.772258

0.00131

21

TNC

Tenascin C

P24821

Up- regulated

2.962339

0.00131

22

KRT17

Keratin 17

Q04695

Up-regulated

3.426447

0.00140

23

HNRNPM

Heterogeneous nuclear ribonucleoprotein M

P52272

Up-regulated

2.175227

0.00160

24

ARHGDIB

Rho GDP dissociation inhibitor (GDI) beta

P52566

Up-regulated

2.896509

0.00163

25

RPL8

Ribosomal protein L8

P62917

Up-regulated

3.17935

0.00163

26

SSB

Sjogren syndrome antigen B (Lupas La protein)

P05455

Up-regulated

3.449898

0.00163

27

KRT6A

Keratin 6A

P02538

Up-regulated

2.353024

0.00163

28

CANX

Calnexin

P27824

Up-regulated

2.013662

0.002

29

RPL4

Ribosomal protein L4

P36578

Up-regulated

2.150875

0.002

30

TPM4

Tropomyosin 4

P67936

Up-regulated

3.225065

0.0021

31

HSPA5

Heat shock 70 kDa protein 5

P11021

Up-regulated

2.543512

0.0022

32

ICAM1

Intercellular adhesion molecule 1

P05362

Up-regulated

2.675839

0.0023

33

KRT6C

Keratin 6C

P48668

Up-regulated

2.912393

0.0030

34

HCLS1

Hematopoietic lineage cell-specific protein

P14317

Up-regulated

3.138184

0.0031

35

RPL35

Ribosomal protein L35

P42766

Up-regulated

1.874303

0.0033

36

ALYREF

Aly/REF export factor

Q86V81

Up-regulated

2.72209

0.0034

37

ALDOA

Aldolase A

P04075

Up-regulated

1.903083

0.0037

38

EEF2

Eukaryotic translation elongation factor 2

P13639

Down-regulated

2.377699

0.0037

39

FLG2

Filaggrin family member 2

Q5D862

Up-regulated

− 3.81655

0.0038

40

RPL13

Ribosomal protein L13

P26373

Up-regulated

2.065239

0.0044

41

NAP1L1

Nucleosome assembly protein 1- like 1

P55209

Up-regulated

1.816704

0.0045

42

LCP1

Lymphocyte cytosolic protein 1

P13796

Up-regulated

2.809815

0.0049

43

THRAP3

Thyroid hormone receptor-associated protein 3

Q9W2Y1

Up-regulated

1.786661

0.0049

44

TPM3

Tropomyosin 3

P06753

Up-regulated

2.967553

0.0049

45

PDIA6

Protein disulfide isomerase family A, member 6

Q15084

Up-regulated

2.139193

0.005

46

GBP1

Guanylate binding protein 1

P32455

Up-regulated

3.506012

0.005

47

LSP1

Lymphocyte-specific protein 1

P33241

Up-regulated

2.886226

0.005

48

ERP29

Endoplasmic reticulum protein 29

P30040

Up-regulated

1.705599

0.0063

49

STAT1

Signal transducer and activator of transcription 1

P42224

Up-regulated

2.964521

0.0063

50

TTR

Transthyretin

P02766

Down-regulated

− 3.45411

0.0063

51

CALR

Calreticulin

P27797

Up-regulated

2.376494

0.0064

52

NCL

Nucleolin

P19338

Up-regulated

1.789074

0.007

53

FBP1

Fructose-1,6-bisphosphatase 1

P09467

Up-regulated

2.729622

0.0082

54

AP3D1

Adaptor-related protein complex 3, delta 1 subunit

O14617

Up-regulated

2.361517

0.0082

55

HNRNPC

Heterogeneous nuclear ribonucleoprotein C (C1/C2)

P07910

Up-regulated

2.478044

0.0082

56

LMNB1

Lamin B1

P20700

Up-regulated

1.592511

0.0082

57

HLA-A

Major histocompatibility complex, class I, A

P04439

Upregulated

2.704871

0.0082

58

P4HB

Prolyl 4-hydroxylase, beta polypeptide

P07237

Up-regulated

1.870152

0.0084

59

RPL5

Ribosomal protein L5

P46777

Up-regulated

2.218306

0.0086

60

RRBP1

Ribosome binding protein 1

Q9P2E9

Up-regulated

2.275802

0.0086

61

HNRNPU

Heterogeneous nuclear ribonucleoprotein U

Q00839

Up-regulated

1.740549

0.009

62

SFPQ

Splicing factor proline/glutamine-rich

P23246

Up regulated

2.519103

0.009

63

RPS16

Ribosomal protein S16

P62249

Up-regulated

1.627651

0.0092

64

RPS19

Ribosomal protein S19

P39019

Up-regulated

1.760495

0.0092

65

S100A4

S100 calcium-binding protein A4

P26447

Up-regulated

2.500661

0.0092

66

FTL

Ferritin, a light polypeptide

P02792

Up-regulated

2.170666

0.00923

67

KRT16

Keratin 16

P08779

Up-regulated

3.083072

0.0094

  1. Table Location—Results (Proteomic profile in cutaneous leishmaniasis host tissues
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Clinical Proteomics

ISSN: 1559-0275